Miz Lena's Boy was released in 1973 by RCA Victor, marking Wilson Pickett's debut on this label after leaving Atlantic Records. The album title is a tribute to his mother, Lena Pickett.
Produced by Wilson Pickett and Brad Shapiro, the record was recorded at Muscle Shoals Sound Studio in Alabama. It includes covers of songs by artists such as The Beatles and Stevie Wonder, along with original compositions.
The album did not achieve the commercial success of his earlier Atlantic works, peaking at number 192 on the Billboard 200. Despite this, it is considered an example of early 1970s soul sound.